Canonical cortical microcircuit. One such question is the degree to which computations in different cortical regions of different species can be encapsulated in a single canonical microcircuit: a kind of basic wiring diagram which, although embellished, remains fundamentally In this perspective, Keller and Mrsic-Flogel describe the advantages of predictive processing as a computational framework for understanding cortical function in the context of emerging evidence with a focus on sensory processing. Jan 14, 2015 · Consequently, it remains an important goal to define local microcircuits for a variety of cortical types, in particular, agranular cortical regions. The cortex plays a crucial role in various perceptual and cognitive functions, driven by its basic unit, the canonical cortical microcircuit. Yet, we remain short of a framework that definitively explains the structure-function relationships of this fundamental neuroanatomical motif. We revisit the established idea that message passing among hierar-chical cortical areas implements a form of Bayesian inference . Nov 21, 2012 · Central to the idea of a canonical microcircuit is the notion that a cortical column contains the circuitry necessary to perform requisite computations and that these circuits can be replicated with minor variations throughout the cortex. Specifically, we conciliate quantitative studies of microcircuitry and the functional logic of neuronal computations. Input recipient layer 4 (L4) sends projections to Apr 6, 2016 · The aim of this paper is to provide a deeper knowledge of the canonical cortical circuits to facilitate the translation of this model from in vitro cellular studies to the interpretation of complex human behaviors. As a counterpoint to the striate microcircuit, which may be anchored in an exceptional cytoarchitecture, we here outline a tentative microcircuit for agranular cortex. We focus on the intrinsic connectivity within a cortical column and the extrinsic connections between columns in different cortical areas. Jun 18, 2020 · Motor cortex layer connectivity The canonical microcircuit Gilbert and Wiesel 32 provided one of the first accounts of a simplified cortical microcircuit applicable across cortical areas. Aug 1, 2010 · This chapter focuses on recent experimental and theoretical considerations of the cortical circuits, which suggest that local circuits of cortical neurons are connected in a series of nested positive and negative feedback loops, called “recurrent circuits”. Oct 27, 2015 · Any early graduate student can recite the rules of the canonical cortical microcircuit, which seem to be replicated throughout the brain. This Perspective considers the influential notion of a canonical (cortical) microcircuit in light of recent theories about neuronal processing. This review considers the canonical microcircuit in light of predictive coding. We revisit the established idea that message passing among hierarchical cortical areas implements a form of Bayesian inference Sep 26, 2002 · A century and a decade after Cajal wrote these words, many of the enduring questions of cortical neurobiology that he helped identify remain unanswered. Specifically, we conciliate quantitative studies of microcircuitry and the func-tional logic of neuronal computations. Feb 5, 2025 · Here, we derived a detailed and functional mathematical theory of cortical and thalamic microcircuits underlying visual perception. Jul 25, 2025 · Inspired by the brain, we present a computational architecture based on canonical microcircuits (CMCs)—stereotyped patterns of neurons found ubiquitously throughout the cortex. The approach we followed can be construed as a general methodology by which we can seek to understand cortical function. yqawyxea 2lv5n 0rchkpu lqb 5i xp57 gf 08y qe f04